A clinical case of long-term GIST of the sigmoid colon during TKI therapy and cytoreductive interventions
https://doi.org/10.62546/3034-1477-2025-3-4-35-42
Abstract
Gastrointestinal stromal tumors (GISTs) are a group of rare gastrointestinal neoplasms of mesenchymal origin. Mutations in the C-KIT or PDGFRA genes are key mechanisms for tumor development. The identification of these pathogenetic mechanisms, as well as significant progress in understanding the molecular biology of gastrointestinal stromal tumors, have led to the development of a personalized approach to the treatment of GISTs, which has had a significant impact on improving patient treatment outcomes.
About the Authors
Natalia P. Belyak
St. Petersburg State University; City Clinical Oncology Dispensary
Russian Federation
Russian Federation
St. Petersburg.
Conflict of interests: Natalia P. Belyak and Mark I. Gluzman are an Editorial Board Members for this journal and was not involved in the editorial review or the decision to publish this article. The article underwent the journal’s peerreview process. The authors declare no other conflicts of interest.
Mark I. Gluzman
St. Petersburg State University; City Clinical Oncology Dispensary
Russian Federation
Russian Federation
St. Petersburg.
Conflict of interests: Natalia P. Belyak and Mark I. Gluzman are an Editorial Board Members for this journal and was not involved in the editorial review or the decision to publish this article. The article underwent the journal’s peerreview process. The authors declare no other conflicts of interest.
Natalia V. Smirnova
City Clinical Oncology Dispensary
Russian Federation
Russian Federation
St. Petersburg.
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Review
For citations:
Belyak N.P., Gluzman M.I., Smirnova N.V. A clinical case of long-term GIST of the sigmoid colon during TKI therapy and cytoreductive interventions. Clinical Case in Oncology. 2025;3(4):35-42. (In Russ.) https://doi.org/10.62546/3034-1477-2025-3-4-35-42
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