A case report of HER 2 positive vulvar extramammary Рaget disease
https://doi.org/10.62546/3034-1477-2023-1-1-17-22
Abstract
The low incidence, nonspecific clinical picture and absence of pathognomonic symptoms of vulvar adenocarcinoma make primary diagnosis very difficult. It could take months from the appearance of first symptoms to the final diagnosis and the start of specific treatment.
There are limited options of standard treatment for this pathology. Therefore, attempts to use therapy that has proven itself in the other malignant tumors, based on molecular biological characteristics, are promising.
Overexpression of HER2, which plays an important role in the carcinogenesis processes, is often observed in cases of extramammary Paget’s disease. We report a case of extramammary Paget’s vulvar cancer treated with a combination of cytostatic and targeted anti-HER2 agents.
About the Authors
I. V. Rykov
St. Petersburg Clinical Hospital of the Russian Academy of Sciences; Almazov National Medical Research Centre
Russian Federation
Russian Federation
Rykov Ivan Vladimirovich — 3.1.6, candidate of medical sciences, Head of the Department of Oncology and Palliative Care; associate professor of the department of oncology
194017, St. Petersburg, M.Torez Ave., 72
197341, St. Petersburg, st. Akkuratova, 2
E. K. Kushniruk
City Clinical Oncology Dispensary
Russian Federation
Russian Federation
Kushniruk Evgenia Konstantinovna — 3.1.6, medical oncologist of Cancer Drug Therapy (Chemotherapeutic) Dept No. 10 SPb SBIH
56, Veteranov Ave., St. Petersburg. 198255
G. A. Raskin
St. Petersburg State University; Medical Institute named after Sergey Berezin
Russian Federation
Russian Federation
Raskin Grigory Aleksandrovich — 3.1.6, 3.3.2, DM Sci (habil.), associate professor, deputy chief physician; professor of the Dept of Oncology
197758, Saint-Petersburg, Kurortniy area, Pesochniy village, Karl Marx st., 43
St. Petersburg, 21-line V.O., 8a
References
1. Weinberg D., Gomez-Martinez R.A. Vulvar Cancer // Obstet. Gynecol. Clin. North Am. 2019. Mar; Vol. 46, No. 1. Р. 125–135. doi: 10.1016/j.ogc.2018.09.008. PMID: 30683259.
2. Paget J. On the disease of the mammary areola preceding cancer of the mammary gland // St. Bartholomew, Hosp. Rep. 1874. Vol. 10. Р. 87–89.
3. St. Claire K., Hoover A., Ashck K., Khachmoumne A. Extramammary Paget disease // Dermatol. Online J. 2019. Apr 15; Vol. 25, No. 4. Р. 13030/qt7qg8g292. PMID: 31046904.
4. Lloyd J., Flanagan A.M. Mammary and extramammary Paget’s disease // J. Clin. Pathol. 2000. Oct; Vol. 53, No. 10. Р. 742–749. doi: 10.1136/jcp.53.10.742. PMID: 11064666; PMCID: PMC1731095.
5. Wang E.C., Kwah Y.C., Tan W.P., Lee J.S., Tan S.H. Extramammary Paget disease: Immunohistochemistry is critical to distinguish potential mimickers // Dermatol. Online J. 2012. Sep 15; Vol. 18, No. 9. Р. 4. PMID: 23031371.
6. Masuguchi S., Jinnin M., Fukushima S., Makino T., Sakai K., Inoue Y., Igata T., Ihn H. The expression of HER-2 in extramammary Paget’s disease // Biosci Trends. 2011. Aug; Vol. 5, No. 4. Р. 151–155. doi: 10.5582/bst.2011.v5.4.151. PMID: 21914949.
7. Takahagi S., Noda H., Kamegashira A., Madokoro N., Hori I., Shindo H., Mihara S., Hide M. Metastatic extramammary Paget’s disease treated with paclitaxel and trastuzumab combination chemotherapy // J. Dermatol. 2009. Aug; Vol. 36, No. 8. Р. 457–461. doi: 10.1111/j.1346-8138.2009.00676.x. PMID: 19691751.
8. Sekiguchi N., Kubota S., Noguchi T., Fukushima T., Kobayashi T., Kanda S., Koizumi T., Miyake T., Shirai T., Okuyama R. Experiences of trastuzumab plus paclitaxel combination therapy in metastatic human epidermal growth factor receptor 2-positive extramammary Paget’s disease: Four cases and a review // J. Dermatol. 2020. Nov; Vol. 47, No. 11. Р. 1276–1279. doi: 10.1111/1346-8138.15515. Epub 2020 Jul 24. PMID: 32706146.
9. Wakabayashi S., Togawa Y., Yoneyama K., Suehiro K., Kambe N., Matsue H. Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget’s Disease to Trastuzumab Monotherapy // Case Rep. Dermatol. Med. 2012. Vol. 2012. 401362. doi: 10.1155/2012/401362. Epub 2012 Mar 27. PMID: 23259081; PMCID: PMC3505941.
Review
For citations:
Rykov I.V., Kushniruk E.K., Raskin G.A. A case report of HER 2 positive vulvar extramammary Рaget disease. Clinical Case in Oncology. 2023;1(1):17-22. (In Russ.) https://doi.org/10.62546/3034-1477-2023-1-1-17-22
Views:
535
Email this article 