Collateral blood flow and parasitic blood supply to the tumor as a possible cause of ineffectiveness of transarterial chemoembolization in the treatment of hepatocellular cancer
V. I. Malkevich,
P. V. Balakhnin,
A. S. Shmelev,
K. V. Kozubova,
I. A. Burovik,
N. V. Popova,
M. S. Dinikin,
V. Yu. Pogrebnyakov,
R. V. Orlova https://doi.org/10.62546/3034-1477-2025-3-1-53-61
Abstract
A clinical case of ineffectiveness of four-fold transarterial chemoembolization of hepatocellular carcinoma is presented, which was caused by the formation of parasitic blood supply to the tumor from extrahepatic sources.
About the Authors
V. I. Malkevich
N.N. Petrov National Medical Research Centre of Oncology
Russian Federation
Russian Federation
Vasilii I. Malkevich
Pesochny, Leningradskaya str, 70, St. Petersburg, 197758
P. V. Balakhnin
N.N. Petrov National Medical Research Centre of Oncology
Russian Federation
Russian Federation
Pavel V. Balakhnin
Pesochny, Leningradskaya str, 70, St. Petersburg, 197758
A. S. Shmelev
N.N. Petrov National Medical Research Centre of Oncology
Russian Federation
Russian Federation
Aleksei S. Shmelev
Pesochny, Leningradskaya str, 70, St. Petersburg, 197758
K. V. Kozubova
N.N. Petrov National Medical Research Centre of Oncology
Russian Federation
Russian Federation
Kseniya V. Kozubova
Pesochny, Leningradskaya str, 70, St. Petersburg, 197758
I. A. Burovik
N.N. Petrov National Medical Research Centre of Oncology
Russian Federation
Russian Federation
Ilya A. Burovik
Pesochny, Leningradskaya str, 70, St. Petersburg, 197758
N. V. Popova
N.N. Petrov National Medical Research Centre of Oncology
Russian Federation
Russian Federation
Natalia V. Popova
Pesochny, Leningradskaya str, 70, St. Petersburg, 197758
M. S. Dinikin
St. Petersburg City Clinical Oncology Dispensary
Russian Federation
Russian Federation
Mikhail S. Dinikin
56 Veteranov Ave., St. Petersburg, 193318
V. Yu. Pogrebnyakov
St. Petersburg City Clinical Oncology Dispensary
Russian Federation
Russian Federation
Vladimir Yu. Pogrebnyakov
56 Veteranov Ave., St. Petersburg, 193318
R. V. Orlova
St. Petersburg City Clinical Oncology Dispensary
Russian Federation
Russian Federation
Rashida V. Orlova
56 Veteranov Ave., St. Petersburg, 193318
References
1. Breder V.V., Bazin I.S., Balakhnin P.V. et al. Practical recommendations for drug treatment of patients with malignant tumors of the liver and biliary system. Malignant tumors, 2022, Vol. 12, No. 3S2–1, рр. 467–529 (In Russ.).
2. Balakhnin P.V., Shmelev A.S., Shachinov E.G. The role of surgical technologies in the treatment of virus-associated tumors on the example of hepatocellular cancer. Practical oncology, 2018, Vol. 19, No. 4, рр. 348–377 (In Russ.).
3. Krupa K., Fudalej M., Cencelewicz-Lesikow A. еt al. Current Treatment Methods in Hepatocellular Carcinoma // Cancers (Basel). 2024. Dec 4; Vol. 16, No. 23. Р. 4059. doi: 10.3390/cancers16234059.
4. Shabunin A.V., Bedin V.V., Grekov D.N., Tavobilov M.M., Drozdov P.A., Lebedev S.S., Karpov A.A., Chechenin G.M., Tsurkan V.A. Hepatocellular carcinoma. Current trends and results of surgical treatment. Annals of surgical hepatology, 2022, Vol. 27, No. 3, рр. 22–32 (In Russ.). doi.org/10.16931/1995-5464.2022-3-22-32.
5. Benkö T., König J., Theysohn J.M. еt al. Bridging treatment prior to liver transplantation for hepatocellular carcinoma: radioembolization or transarterial chemoembolization? // Eur. J. Med. Res. 2022. May 26; Vol. 27, No. 1. Р. 74. doi: 10.1186/s40001-022-00708-w.
6. Jotz R.F., Horbe A.F., Coral G.P. et al. Results of transarterial chemoembolization of hepatocellular carcinoma as a bridging therapy to liver transplantation // Radiol. Bras. 2023. Sep-Oct; Vol. 56, No. 5. Р. 235–241. doi: 10.1590/0100-3984.2023.0040.
7. Dolgushin B.I., Tarazov P.G., Pogrebnyakov I.V. et al. Standards for the transarterial chemoembolization procedure in the treatment of patients with hepatocellular carcinoma: a teaching aid. Moscow: National Medical Research Center of Oncology named after N. N. Blokhin, 2024. 66 p. (In Russ.).
8. Granov D.A., Polekhin A.S., Tarazov P.G. et al. Chemoembolization of hepatic arteries in patients with hepatocellular carcinoma against the background of cirrhosis before liver transplantation: prognostic value of alpha-fetoprotein concentration. Bulletin of Transplantology and Artificial Organs, 2020, Vol. 22, No. 4, pp. 52–57 (In Russ.).
9. Breder V.V., Dzhanyan I.A., Pitkevich M.Yu., et al. Transarterial chemoembolization in the treatment of patients with localized inoperable hepatocellular carcinoma: long-term results and prognostic factors. Issues of oncology, 2018, Vol. 64, No. 6, pp. 793–798 (In Russ.).
10. Solim L.A., Atasoy D., Vogl T.J. The efficacy of cone-beam computed tomography-guided transcatheter arterial chemoembolization in hepatocellular carcinoma survival: A systematic review // J. Clin. Imaging. Sci. 2024. Jul 17; Vol. 14. Р. 25. doi: 10.25259/JCIS_32_2024.
11. Rash C., Lee E., Klinsky S., Angel W. Case study of inferior adrenal artery as an extrahepatic collateral arterial supply to hepatocellular carcinoma // Radiol. Case Rep. 2024. Oct 15; Vol. 20, No. 1. Р. 129–132. doi: 10.1016/j.radcr.2024.10.026.
12. Balakhnin P.V., Tarazov P.G. et al. Long-term regional chemotherapy of colorectal liver metastasis: Role of aberrant hepatic arterial anatomy identification in placement of implantable hepatic arterial infusion devices // Problems in Oncology. 2003. Vol. 49, No. 5. P. 588–594.
13. Hieu L.T., Van Thanh L., Van Quang V. еt al. Spinal cord ischemia after transcatheter artery chemoembolization for hepatocellular carcinoma: A case-report // Int. J. Surg. Case Rep. 2023. May; Vol. 106. Р. 108258. doi: 10.1016/j.ijscr.2023.108258.
14. Alhussaini A., Qazi S.A., AlZahrani Y.A. Successful Transcatheter Arterial Radioembolization of Hepatocellular Carcinoma Via Left Internal Mammary Artery: A Case Report // Cureus. 2022. Mar 8; Vol. 14, No. 3. Р. e22954. doi: 10.7759/cureus.22954.
15. Gish R.C., Scott J.A., Yu H. Transarterial chemoembolization of hepatocellular carcinoma via extrahepatic collateral artery from a supraduodenal and cystic artery trunk, originating from the gastroduodenal artery: A case report // Radiol. Case Rep. 2021. Aug 12; Vol. 16, No. 10. Р. 3064–3067. doi: 10.1016/j.radcr.2021.07.041.
16. Chiu S.H., Chang P.Y., Shih Y.L. et al. Efficacy and Safety of Supplemental Transarterial Chemoembolization Through Extrahepatic Collateral Arteries with Drug-eluting Beads: Treatment for Unresectable Hepatocellular Carcinoma // Drug. Des. Devel. Ther. 2020. Nov 17; Vol. 14. Р. 5029–5041. doi: 10.2147/DDDT.S266470.
17. Balakhnin P.V., Belyaev A.M., Bagnenko S.S. et al. Flat detector computed tomography technologies in interventional oncology: diagnostics, staging and treatment of hepatocellular cancer. High-tech medicine, 2023, Vol. 1, No. 1, рр. 6–25 (In Russ.).
18. Balakhnin P.V. The importance of variants of arterial anatomy of the liver for performing interventional radiological procedures: specialty 14.01.13 Radiation diagnostics, radiation therapy: dis. … candidate of medical sciences / Balakhnin Pavel Vasilievich. St. Petersburg, 2012. 111 p. (In Russ.).
Review
For citations:
Malkevich V.I., Balakhnin P.V., Shmelev A.S., Kozubova K.V., Burovik I.A., Popova N.V., Dinikin M.S., Pogrebnyakov V.Yu., Orlova R.V. Collateral blood flow and parasitic blood supply to the tumor as a possible cause of ineffectiveness of transarterial chemoembolization in the treatment of hepatocellular cancer. Clinical Case in Oncology. 2025;3(1):53-61. (In Russ.) https://doi.org/10.62546/3034-1477-2025-3-1-53-61
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