Evolution of photodynamic therapy application in the treatment of malignant neoplasms
https://doi.org/10.62546/3034-1477-2024-2-3-19-33
Abstract
Photodynamic therapy (PDT) is a modern non-invasive technique of antitumor treatment. In its basis local or systemic application light-sensitive compound-photosensitizer (FS), which is selectively nakuplen in pathological tissue. In the interaction with the light of a certain length of the wave in the presence of oxygen in the fabric of the triggered photochemical process, driving to the gibel cell and activation of the immune response. Accumulation of FS in the affected tissues and targeted light allows to achieve high selectivity of action and minimal damage to surrounding tissues. Absence of resistance to PDT and possibility of combination with traditional methods of tumor treatment (surgical, radiation, systemic antitumor therapy) increase efficiency of PDT use in treatment of malignant neoplasms of different localizations, including palliative care.
Supporting agencies: The work performed without external funding.
About the Authors
E. F. Stranadko
Skobelkin Scientific and Practical Center for Laser Medicine FMBA
Russian Federation
Russian Federation
40 Studencheskaya Str., Moscow 121165
E. N. Pavlova
City Clinical Oncological Dispensary
Russian Federation
Russian Federation
Pavlova Elena Naumovna
56 Veteranov pr., St. Petersburg 198255
A. V. Anisimova
City Clinical Oncological Dispensary
Russian Federation
Russian Federation
56 Veteranov pr., St. Petersburg 198255
D. A. Polezhaev
City Clinical Oncological Dispensary; Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
56 Veteranov pr., St. Petersburg 198255; 6–8 L. Tolstoy Str., St. Petersburg 197022
O. I. Fedorova
City Clinical Oncological Dispensary
Russian Federation
Russian Federation
56 Veteranov pr., St. Petersburg 198255
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For citations:
Stranadko E.F., Pavlova E.N., Anisimova A.V., Polezhaev D.A., Fedorova O.I. Evolution of photodynamic therapy application in the treatment of malignant neoplasms. Clinical Case in Oncology. 2024;2(3):19-33. (In Russ.) https://doi.org/10.62546/3034-1477-2024-2-3-19-33
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